Pestilence - is a giant, GLOW-induced monstrosity created by Dr.Apparently, he 'smells as bad as a bum at the Barfly, but at least looks like he can throw a punch'. At one point in the game, he asks Kyle to get rid of the cockroaches in his infested apartment to keep the health inspector away. He also trains people for money in Tiger’s gym. He also helps Kyle by telling him about Lou 'The Skin' designing the tattoo on the mysterious person in Cody’s picture. If paid $100, he’ll help Kyle save 2-Ill at the beginning of the game. Paco - He is a tattoo artist that lives in the same building as Kyle, and is trained as a boxer.Afterwards, she appears in various parts of the city with Kyle having the option to play the matching game again, in which she’ll allude to what Kyle will have to deal with in the near future. It is insinuated that she and Cody had been intimate. Once Kyle is successful, Madame Celeste tells Kyle some information and gives him Cody’s house key. The mystic asks him to play a magic card matching game, before she tells him the future. Vanessa sends Kyle to her psychic parlor to get information on Cody’s whereabouts. Madame Celeste - She is a fortune teller in Kyle’s neighborhood.Kyle defeated the Horseman War, but was only seconds too late to save Sims from decapitation by Famine. Bella sent out his two of his four horsemen to take care of them. Only Sims and Kyle were left when they were able to enter the church. Unfortunately Sims lost all his men after Father Bella, the mastermind behind the drug, threw grenades at them while simultaneously a small army of Glowheads attacked them. When Sims traced the source of GLOW to a church in Little Italy during the city riots, Sims along with Kyle and whatever officers he had left attempted to storm the church. Sims also sought to arrest Cody for using GLOW, a highly addictive drug that increases the physical attributes of the user. He wanted Kyle not to get involved due to the danger Cody was in. By the request of his sister, Vanessa, he assisted her boyfriend, Kyle into looking for his missing brother. Sergeant Sims - He is a deep cover cop for the MCPD (Metro City Police Department).While Vanessa tends to Kyle and Cody in the hospital, she keeps her brother’s badge as a remembrance. Kyle eventually saved Cody and the city, but the end result cost her the bar and the life of her brother Sergeant Sims in the final battles. During the GLOW-induced riots in Metro City, Kyle and ex- Mad Gear member 2-Ill (formerly known as Two P) saved her life. She also has her brother on the MCPD in aiding Kyle in his search. When Kyle’s brother, Cody, is taken captive by The Stiff in her bar, Vanessa does her best to provide information and ideas to Kyle to find Cody.

Vanessa Sims - is the girlfriend of Kyle and the owner and bartender of the Barfly Lounge in Metro City.Progress will resume at the last checkpoint rather than the character's last position. The game's save system can only be used once the player decides to quit the game. However, the game is over when the life bar is empty. Kyle, Cody, Guy and Haggar are all playable characters in arcade mode. It does not have upgradable movesets, counters or instinct abilities. The arcade mode is a no-frills 3D brawler for 1 or 2 players. An 'instinct' system allows players to counter opponents' attacks, as well as make their attacks more powerful. Players earn money through pit fights and side missions, upgrading Kyle's moveset by training in various gyms in Metro City while progressing through the game. The story mode, which is exclusively single player, has ten minigames, including cockroach stomping, arm-wrestling, slide puzzles, shooting contests and the classic car bash. Final Fight: Streetwise is a 3D beat 'em up game.

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